buprenorphine + fluoxetine

use alternative or monitor respiratory rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome (additive effects)

tamsulosin + fluoxetine

avoid combo if also combined w/ strong CYP3A4 inhibitor; otherwise, monitor BP, especially w/ tamsulosin dose >0.4 mg: combo may incr. tamsulosin levels, risk of hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited)

buprenorphine + felbamate

monitor respiratory rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control; may decr. buprenorphine levels, efficacy (additive effects; antagonistic effects, buprenorphine may decr. seizure threshold; hepatic metabolism induced)

buprenorphine + tamsulosin

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

felbamate + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)