epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Fortesta
    testosterone transdermal
  • remove hydrocodone
    generic
  • remove olmesartan medoxomil/ hydrochlorothiazide
    generic

multicheck MultiCheck Results - 4 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Fortesta (testosterone transdermal) + olmesartan medoxomil/hydrochlorothiazide (generic)

Monitor/Modify Tx


testosterone + hydrochlorothiazide

monitor BP, calcium, especially in cancer pts at incr. risk: combo may incr. risk of hypercalcemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

testosterone + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face hydrocodone (generic) + olmesartan medoxomil/hydrochlorothiazide (generic)

Monitor/Modify Tx


hydrocodone + hydrochlorothiazide

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope; may decr. hydrochlorothiazide efficacy (additive effects; antagonistic effects, opioids may induce antidiuretic hormone release)

hydrocodone + olmesartan medoxomil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

Additional Considerations

Smiley face Smiley face hydrocodone

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information