chlorpheniramine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

chlorpheniramine + codeine

avoid combo if antitussive use; otherwise monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

ibuprofen + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

pseudoephedrine + caffeine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

butalbital + nicardipine

use alternative or monitor BP: combo may decr. nicardipine levels, efficacy (hepatic metabolism induced)

codeine + nicardipine

use alternative or monitor respiratory rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine; additive effects)

caffeine + nicardipine

monitor BP; avoid excessive caffeine intake: combo may decr. antihypertensive agent efficacy (antagonistic effects)

ibuprofen + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

pseudoephedrine + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)