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Interaction Check

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Selected Drugs Clear All

  • remove Advil Sinus Congestion & Pain
    ibuprofen/ phenylephrine
  • remove Humira
    adalimumab
  • remove methocarbamol
    generic
  • remove Yaz
    drospirenone/ ethinyl estradiol

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Advil Sinus Congestion & Pain (ibuprofen/ phenylephrine) + Yaz (drospirenone/ ethinyl estradiol)

Monitor/Modify Tx


ibuprofen + drospirenone (contraceptive)

monitor potassium, thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of hyperkalemia, thromboembolism (additive effects)

ibuprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

phenylephrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Advil Sinus Congestion & Pain

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face adalimumab in Humira

caution advised with narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx with immune modulators may reverse this effect, resulting in altered levels of concomitant drugs

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