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Interaction Check

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Selected Drugs Clear All

  • remove Advil Sinus Congestion & Pain
    ibuprofen/ phenylephrine
  • remove Kurvelo
    levonorgestrel/ ethinyl estradiol
  • remove Rivelsa
    levonorgestrel/ ethinyl estradiol
  • remove Tylenol Sinus + Headache Daytime
    acetaminophen/ phenylephrine

multicheck MultiCheck Results - 14 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Advil Sinus Congestion & Pain (ibuprofen/ phenylephrine) + Tylenol Sinus + Headache Daytime (acetaminophen/ phenylephrine)

Avoid/Use Alternative


phenylephrine + phenylephrine

avoid combo: combo may incr. risk of HTN, tachycardia (additive effects, duplicate therapy)

Monitor/Modify Tx


ibuprofen + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Kurvelo (levonorgestrel/ ethinyl estradiol) + Rivelsa (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

levonorgestrel (contraceptive) + levonorgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Advil Sinus Congestion & Pain (ibuprofen/ phenylephrine) + Kurvelo (levonorgestrel/ ethinyl estradiol)

Monitor/Modify Tx


ibuprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ibuprofen + levonorgestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

phenylephrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Advil Sinus Congestion & Pain (ibuprofen/ phenylephrine) + Rivelsa (levonorgestrel/ ethinyl estradiol)

Monitor/Modify Tx


ibuprofen + ethinyl estradiol (contraceptive)

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ibuprofen + levonorgestrel (contraceptive)

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

phenylephrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Kurvelo (levonorgestrel/ ethinyl estradiol) + Tylenol Sinus + Headache Daytime (acetaminophen/ phenylephrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + acetaminophen

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

ethinyl estradiol (contraceptive) + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Rivelsa (levonorgestrel/ ethinyl estradiol) + Tylenol Sinus + Headache Daytime (acetaminophen/ phenylephrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + acetaminophen

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

ethinyl estradiol (contraceptive) + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Advil Sinus Congestion & Pain, Tylenol Sinus + Headache Daytime

add MAO inhibitor to Interaction Check if recent (14 days) use

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