palonosetron + fluoxetine

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

palonosetron + solifenacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

metoclopramide + fluoxetine

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: use alternative or decr. metoclopramide dose 50% and monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. metoclopramide levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

metoclopramide + solifenacin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

oxybate + solifenacin

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

oxybate + oxcarbazepine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

palonosetron + metoclopramide

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

carvedilol + metoclopramide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

carvedilol + licorice

monitor BP w/ large amounts of licorice: combo may decr. antihypertensive agent efficacy (antagonistic effects)

carvedilol + phentermine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

carvedilol + propofol

monitor BP, HR: combo may incr. risk of severe hypotension, bradycardia (additive effects)

carvedilol + fluoxetine

monitor BP, HR: combo may incr. carvedilol levels, risk of hypotension, bradycardia, AV block, other adverse effects (hepatic metab. inhibited)

carvedilol + oxcarbazepine

monitor BP, HR: combo may decr. carvedilol levels, efficacy (P-gp-mediated transport possibly induced)

metoclopramide + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

metoclopramide + phentermine

monitor BP: combo may incr. risk of HTN (additive effects)

licorice + phentermine

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

propofol + oxcarbazepine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, propofol may decr. seizure threshold)

fluoxetine + oxcarbazepine

monitor sodium: combo may incr. risk of hyponatremia, seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)

amoxicillin + oxcarbazepine

caution advised if seizure disorder use, especially w/ high amoxicillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, amoxicillin may decr. seizure threshold)

phentermine + oxcarbazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, phentermine may decr. seizure threshold)

fluoxetine + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

fluoxetine + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dantrolene + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dantrolene + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

solifenacin + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)