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Interaction Check

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Selected Drugs Clear All

  • remove Cardizem
    diltiazem
  • remove Ceftin
    cefuroxime axetil
  • remove Depakote Sprinkles
    divalproex sodium
  • remove desonide topical
    generic
  • remove diflunisal
    generic
  • remove Diuril
    chlorothiazide

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Cardizem (diltiazem) + diflunisal (generic)

Monitor/Modify Tx


diltiazem + diflunisal

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Smiley face Smiley face Depakote Sprinkles (divalproex sodium) + diflunisal (generic)

Monitor/Modify Tx


valproic acid + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

Smiley face Smiley face diflunisal (generic) + Diuril (chlorothiazide)

Monitor/Modify Tx


diflunisal + chlorothiazide

monitor renal fxn, BP: combo may incr. risk of renal impairment; may decr. chlorothiazide efficacy (additive effects; antagonistic effects)

Additional Considerations

Smiley face Smiley face diltiazem in Cardizem

avoid combo with beverages or products containing ethanol and Cardizem CD, Cartia XT, some generic extended-release (ER) capsules; combo may incr. diltiazem release rate, levels, risk of adverse effects, decr. duration of efficacy

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