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Interaction Check

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Selected Drugs Clear All

  • remove Excedrin Migraine
    acetaminophen/ aspirin/ caffeine
  • remove Stoboclo (denosumab-bmwo)
    denosumab
  • remove Theraflu Daytime Severe Cold Relief
    acetaminophen/ dextromethorphan
  • remove Uribel
    methenamine/ sodium phosphate/ phenyl salicylate/ methylene blue/ hyoscyamine
  • remove Vyleesi
    bremelanotide

multicheck MultiCheck Results - 8 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Theraflu Daytime Severe Cold Relief (acetaminophen/ dextromethorphan)

Avoid/Use Alternative


acetaminophen + acetaminophen

limit acetaminophen from all sources to standard max acetaminophen doses: combo may incr. acetaminophen levels, risk of hepatotoxicity, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Theraflu Daytime Severe Cold Relief (acetaminophen/ dextromethorphan) + Uribel (methenamine/ sodium phosphate/ phenyl salicylate/ methylene blue/ hyoscyamine)

Avoid/Use Alternative


dextromethorphan + methylene blue oral

use alternative or monitor serotonin syndrome sx w/in 14 days of methylene blue use, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

Caution Advised


acetaminophen + hyoscyamine

caution advised w/ oral acetaminophen: combo may decr. peak acetaminophen levels, delay analgesic onset, efficacy (absorption delayed, possibly decreased)

Monitor/Modify Tx

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Uribel (methenamine/ sodium phosphate/ phenyl salicylate/ methylene blue/ hyoscyamine)

Monitor/Modify Tx


caffeine + hyoscyamine

monitor HR; avoid excessive caffeine intake: combo may incr. risk of tachycardia (additive effects)

Caution Advised


acetaminophen + hyoscyamine

caution advised w/ oral acetaminophen: combo may decr. peak acetaminophen levels, delay analgesic onset, efficacy (absorption delayed, possibly decreased)

aspirin + phenyl salicylate

caution advised: combo may incr. salicylate levels, risk of adverse effects (additive effects, duplicate therapy)

Caution Advised

Smiley face Smiley face Excedrin Migraine (acetaminophen/ aspirin/ caffeine) + Vyleesi (bremelanotide)

Caution Advised


acetaminophen + bremelanotide

caution advised w/ oral acetaminophen: combo may decr. peak acetaminophen levels, delay analgesic onset, efficacy (absorption delayed, possibly decreased)

Smiley face Smiley face Theraflu Daytime Severe Cold Relief (acetaminophen/ dextromethorphan) + Vyleesi (bremelanotide)

Caution Advised


acetaminophen + bremelanotide

caution advised w/ oral acetaminophen: combo may decr. peak acetaminophen levels, delay analgesic onset, efficacy (absorption delayed, possibly decreased)

Additional Considerations

Smiley face Smiley face dextromethorphan in Theraflu Daytime Severe Cold Relief

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face bremelanotide in Vyleesi

avoid combo with oral drugs requiring quick onset and/or efficacy dependent on threshold concentrations; bremelanotide delays gastric emptying, may reduce rate and extent of oral drug absorption

Smiley face Smiley face hyoscyamine in Uribel

caution advised with concurrent oral drugs requiring rapid onset; hyoscyamine delays gastric emptying, may alter absorption of concomitant oral drugs

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