Interaction Check

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MultiCheck Results - 3 Interactions

Avoid/Use Alternative
Dilacor XR (diltiazem) + Priftin (rifapentine)
Avoid/Use Alternative diltiazem + rifapentine use alternative: combo may decr. diltiazem levels, efficacy (hepatic metabolism induced, P-gp-mediated transport possibly induced)
Priftin (rifapentine) + Triumeq (abacavir/ dolutegravir/ lamivudine)
Avoid/Use Alternative rifapentine + dolutegravir avoid combo if rifapentine daily or dolutegravir bid use; monitor virologic response w/ rifapentine weekly and dolutegravir daily: combo may decr. dolutegravir levels, efficacy (hepatic metabolism induced, P-gp-mediated transport induced, UGT induced)
Monitor/Modify Tx
Children's Robitussin Cough & Cold CF (dextromethorphan/ phenylephrine/ guaifenesin) + Dilacor XR (diltiazem)
Monitor/Modify Tx phenylephrine + diltiazem monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
Additional Considerations
diltiazem in Dilacor XR
avoid combo with beverages or products containing ethanol and Cardizem CD, Cartia XT, some generic extended-release (ER) capsules; combo may incr. diltiazem release rate, levels, risk of adverse effects, decr. duration of efficacy
phenylephrine in Children's Robitussin Cough & Cold CF
add MAO inhibitor to Interaction Check if recent (14 days) use
dextromethorphan in Children's Robitussin Cough & Cold CF
add MAO inhibitor to Interaction Check if recent (14 days) use
abacavir in Triumeq
some formulations of abacavir contain sorbitol
lamivudine in Triumeq
avoid combo of lamivudine oral solution with oral products containing sorbitol; may give lamivudine tab formulation or monitor virologic response more frequently if combo cannot be avoided; sorbitol may decr. bioavailability of lamivudine, resulting in decr. levels, efficacy