Interaction Check

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MultiCheck Results - 6 Interactions

Monitor/Modify Tx
Dilantin (phenytoin) + Epidiolex (cannabidiol (CBD))
Monitor/Modify Tx phenytoin + cannabidiol monitor phenytoin levels; consider cannabidiol dose adjustment: combo may incr. phenytoin levels, risk of CNS depression, psychomotor impairment, other adverse effects; may decr. cannabidiol and active metabolite levels, efficacy (hepatic metabolism inhibited, additive effects; hepatic metabolism induced)
Dilantin (phenytoin) + perampanel (generic)
Monitor/Modify Tx phenytoin + perampanel incr. perampanel start dose to 4 mg/day: combo may decr. perampanel levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metabolism induced; additive effects)
Dilantin (phenytoin) + Zonisade (zonisamide)
Monitor/Modify Tx phenytoin + zonisamide consider zonisamide dose adjustment: combo may decr. zonisamide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metabolism induced; additive effects)
Caution Advised
Epidiolex (cannabidiol (CBD)) + perampanel (generic)
Caution Advised cannabidiol + perampanel caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Epidiolex (cannabidiol (CBD)) + Zonisade (zonisamide)
Caution Advised cannabidiol + zonisamide caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
perampanel (generic) + Zonisade (zonisamide)
Caution Advised perampanel + zonisamide caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)