epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Balcoltra
    levonorgestrel/ ethinyl estradiol
  • remove Elinest
    norgestrel/ ethinyl estradiol
  • remove Myzilra
    levonorgestrel/ ethinyl estradiol
  • remove Sudafed PE Head Congestion + Pain
    ibuprofen/ phenylephrine

multicheck MultiCheck Results - 15 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Balcoltra (levonorgestrel/ ethinyl estradiol) + Elinest (norgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

levonorgestrel (contraceptive) + norgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Balcoltra (levonorgestrel/ ethinyl estradiol) + Myzilra (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

levonorgestrel (contraceptive) + levonorgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Elinest (norgestrel/ ethinyl estradiol) + Myzilra (levonorgestrel/ ethinyl estradiol)

Avoid/Use Alternative


ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

norgestrel (contraceptive) + levonorgestrel (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Balcoltra (levonorgestrel/ ethinyl estradiol) + Sudafed PE Head Congestion + Pain (ibuprofen/ phenylephrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + ibuprofen

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ethinyl estradiol (contraceptive) + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

levonorgestrel (contraceptive) + ibuprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face Elinest (norgestrel/ ethinyl estradiol) + Sudafed PE Head Congestion + Pain (ibuprofen/ phenylephrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + ibuprofen

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ethinyl estradiol (contraceptive) + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

norgestrel (contraceptive) + ibuprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Smiley face Smiley face Myzilra (levonorgestrel/ ethinyl estradiol) + Sudafed PE Head Congestion + Pain (ibuprofen/ phenylephrine)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + ibuprofen

monitor BP, thrombosis s/sx; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

ethinyl estradiol (contraceptive) + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

levonorgestrel (contraceptive) + ibuprofen

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective ibuprofen dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Sudafed PE Head Congestion + Pain

add MAO inhibitor to Interaction Check if recent (14 days) use

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information