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Interaction Check

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Selected Drugs Clear All

  • remove Esgic-Plus
    butalbital/ acetaminophen/ caffeine
  • remove Mono-Linyah
    norgestimate/ ethinyl estradiol
  • remove Vicks Sinex Severe Nasal Spray
    oxymetazoline nasal

multicheck MultiCheck Results - 6 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Esgic-Plus (butalbital/ acetaminophen/ caffeine) + Mono-Linyah (norgestimate/ ethinyl estradiol)

Avoid/Use Alternative


butalbital + ethinyl estradiol (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after butalbital tx: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metabolism induced, UGT induced)

butalbital + norgestimate (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after butalbital tx: combo may decr. norgestimate and active metabolites levels, contraceptive efficacy (hepatic metabolism induced)

Monitor/Modify Tx


acetaminophen + ethinyl estradiol (contraceptive)

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

caffeine + ethinyl estradiol (contraceptive)

monitor BP; avoid excessive caffeine intake: combo may incr. caffeine levels, risk of HTN, other adverse effects (hepatic metabolism inhibited, additive effects)

Monitor/Modify Tx

Smiley face Smiley face Esgic-Plus (butalbital/ acetaminophen/ caffeine) + Vicks Sinex Severe Nasal Spray (oxymetazoline nasal)

Monitor/Modify Tx


caffeine + oxymetazoline nasal

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

Smiley face Smiley face Mono-Linyah (norgestimate/ ethinyl estradiol) + Vicks Sinex Severe Nasal Spray (oxymetazoline nasal)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

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