Selected Drugs Clear All
MultiCheck Results
- 1
Interaction
Avoid/Use Alternative |
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Duramorph
(morphine sulfate) + Zubsolv
(buprenorphine/ naloxone) |
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Avoid/Use Alternativemorphine + buprenorphine use alternative or monitor withdrawal sx, respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. morphine efficacy, precipitate withdrawal in opioid dependent patients; may incr. risk of profound CNS and respiratory depression, psychomotor impairment, serotonin syndrome, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus (antagonistic effects; additive effects) |
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Additional Considerations |
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buprenorphine
in Zubsolv
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use |
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naloxone (abuse deterrent)
in Zubsolv
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no pharmacologic activity when administered as directed |
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morphine
in Duramorph
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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