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Interaction Check

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Selected Drugs Clear All

  • remove Imvexxy
    estradiol vaginal
  • remove Khindivi
    hydrocortisone
  • remove Larin Fe 1/ 20
    norethindrone/ ethinyl estradiol

multicheck MultiCheck Results - 4 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Imvexxy (estradiol vaginal) + Larin Fe 1/20 (norethindrone/ ethinyl estradiol)

Avoid/Use Alternative


estradiol (hormone replacement) + ethinyl estradiol (contraceptive)

avoid combo: combo may incr. risk of thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx


estradiol (hormone replacement) + norethindrone (contraceptive)

monitor thrombosis s/sx: combo may incr. risk of thromboembolism (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Imvexxy (estradiol vaginal) + Khindivi (hydrocortisone)

Monitor/Modify Tx


estradiol (hormone replacement) + hydrocortisone

consider hydrocortisone dose adjustment: combo may decr. corticosteroid levels, efficacy (altered cortisol-binding globulin activity)

Smiley face Smiley face Khindivi (hydrocortisone) + Larin Fe 1/20 (norethindrone/ ethinyl estradiol)

Monitor/Modify Tx


hydrocortisone + ethinyl estradiol (contraceptive)

monitor BP; consider hydrocortisone dose adjustment: combo may decr. hydrocortisone levels, efficacy; may incr. risk of HTN (altered cortisol-binding globulin activity; additive effects)

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