Selected Drugs Clear All
MultiCheck Results
- 20
Interactions
Contraindicated |
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Austedo XR
(deutetrabenazine) + Emsam
(selegiline transdermal) |
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Contraindicateddeutetrabenazine + selegiline transdermal contraindicated w/in 14 days of selegiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (increased synaptic monoamine neurotransmitters, additive effects) |
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Emsam
(selegiline transdermal) + Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) |
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Contraindicatedselegiline transdermal + dextromethorphan contraindicated w/in 14 days of selegiline transdermal or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects) selegiline transdermal + doxylamine contraindicated if doxylamine use for pregnancy-related nausea/vomiting, otherwise avoid combo w/in 14 days of selegiline use: combo may incr. risk of CNS depression, psychomotor impairment; may prolong and intensify anticholinergic effects of antihistamines (additive effects; mechanism unknown) Avoid/Use Alternativeselegiline transdermal + phenylephrine avoid combo w/in 14 days of selegiline use: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects) |
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Emsam
(selegiline transdermal) + Zyban
(bupropion hydrochloride) |
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Contraindicatedselegiline transdermal + bupropion contraindicated w/in 14 days of selegiline or bupropion use: combo may incr. risk of HTN (incl. hypertensive crisis), seizures (additive effects) |
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Avoid/Use Alternative |
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Austedo XR
(deutetrabenazine) + Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) |
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Avoid/Use Alternativedeutetrabenazine + doxylamine avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects) |
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Eliphos
(calcium acetate) + K-Phos Original
(potassium acid phosphate) |
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Avoid/Use Alternativecalcium acetate + potassium acid phosphate avoid combo or give phosphate 2h before: combo may decr. phosphate efficacy (absorption decreased) |
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Monitor/Modify Tx |
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Austedo XR
(deutetrabenazine) + Zyban
(bupropion hydrochloride) |
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Monitor/Modify Txdeutetrabenazine + bupropion monitor ECG; adjust max deutetrabenazine dose to 36 mg/day: combo may incr. deutetrabenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited) |
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Cardizem CD
(diltiazem) + Co Q10
(coenzyme Q-10) |
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Monitor/Modify Txdiltiazem + coenzyme Q-10 monitor BP: combo may incr. risk of hypotension (additive effects) |
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Cardizem CD
(diltiazem) + Daysee
(levonorgestrel/ ethinyl estradiol) |
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Monitor/Modify Txdiltiazem + ethinyl estradiol (contraceptive) monitor BP, thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metab. inhibited; antagonistic effects) |
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Cardizem CD
(diltiazem) + diazoxide
(generic) |
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Monitor/Modify Txdiltiazem + diazoxide monitor BP: combo may incr. risk of hypotension (additive effects) |
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Cardizem CD
(diltiazem) + Emsam
(selegiline transdermal) |
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Monitor/Modify Txdiltiazem + selegiline transdermal monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects) |
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Cardizem CD
(diltiazem) + Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) |
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Monitor/Modify Txdiltiazem + phenylephrine monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects) |
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Cardizem CD
(diltiazem) + Zyban
(bupropion hydrochloride) |
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Monitor/Modify Txdiltiazem + bupropion monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects) |
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Co Q10
(coenzyme Q-10) + Emsam
(selegiline transdermal) |
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Monitor/Modify Txcoenzyme Q-10 + selegiline transdermal monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects) |
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Daysee
(levonorgestrel/ ethinyl estradiol) + Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) |
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Monitor/Modify Txethinyl estradiol (contraceptive) + acetaminophen monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown) ethinyl estradiol (contraceptive) + phenylephrine monitor BP: combo may incr. risk of HTN (additive effects) |
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Daysee
(levonorgestrel/ ethinyl estradiol) + Zyban
(bupropion hydrochloride) |
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Monitor/Modify Txethinyl estradiol (contraceptive) + bupropion monitor BP: combo may incr. risk of HTN (additive effects) |
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Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) + Zyban
(bupropion hydrochloride) |
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Monitor/Modify Txphenylephrine + bupropion monitor BP: combo may incr. risk of HTN (additive effects) |
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Caution Advised |
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K-Phos Original
(potassium acid phosphate) + Vicks NyQuil Severe Cold & Flu
(acetaminophen/ doxylamine/ dextromethorphan/ phenylephrine) |
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Caution Advisedpotassium acid phosphate + doxylamine caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration) |
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Additional Considerations |
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diltiazem
in Cardizem CD
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avoid combo with beverages or products containing ethanol and Cardizem CD, Cartia XT, some generic extended-release (ER) capsules; combo may incr. diltiazem release rate, levels, risk of adverse effects, decr. duration of efficacy |
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hydrogen peroxide topical
in Eskata
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Discontinued in US |
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phenylephrine
in Vicks NyQuil Severe Cold & Flu
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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dextromethorphan
in Vicks NyQuil Severe Cold & Flu
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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selegiline transdermal
in Emsam
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add fluoxetine to Interaction Check if recent (5wk) use |
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deutetrabenazine
in Austedo XR
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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calcium acetate
in Eliphos
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consider separating administration from other oral drugs w/ narrow therapeutic index; monitor levels as appropriate, clinical response; calcium acetate may decr. absorption of concomitant oral drugs |
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bupropion
in Zyban
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caution advised w/ concomitant drugs if smoking cessation use; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs add MAO inhibitor to Interaction Check if recent (14 days) use |
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