Interaction Check

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MultiCheck Results - 2 Interactions

Avoid/Use Alternative
Aristada (aripiprazole lauroxil) + Valium (diazepam)
Avoid/Use Alternative aripiprazole lauroxil + diazepam ARISTADA INITIO: avoid combo; ARISTADA: monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)
Monitor/Modify Tx
Luzu (luliconazole topical) + Valium (diazepam)
Monitor/Modify Tx luliconazole topical + diazepam monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)
Additional Considerations
aripiprazole lauroxil in Aristada
drug interactions apply only to Aristada and Aristada Initio (aripiprazole lauroxil, injectable prodrug of aripiprazole); see other aripiprazole products for potentially relevant interactions aripiprazole is a substrate of CYP2D6 and CYP3A4; drug interaction guidance may vary with CYP450 inhibitors if patient is CYP2D6 poor metabolizer (PM) avoid combo with Aristada Initio if also combined with strong CYP2D6 inhibitor, strong CYP3A4 inhibitor and/or major CYP3A4 inducer as dose adjustment not possible; Aristada Initio not interchangeable with Aristada due to different pharmacokinetic profiles