caution advised with drugs metabolized by CYP450 enzymes, especially with narrow therapeutic index; cytokines, like metreleptin, may alter metabolic enzyme formation, resulting in altered levels of concomitant drugs

avoid combo with N-acetyl-DL-leucine or N-acetyl-D-leucine; competition for transporter uptake may decr. levacetylleucine efficacy

separate administration from other oral drugs by >1h; penicillamine may be inactivated by and decr. absorption of concomitant oral drugs

lenacapavir is indicated for treatment of HIV infection (Sunlenca) and HIV pre-exposure prophylaxis (Yeztugo); drug interaction guidance with strong and moderate CYP3A4 inducers varies by indication; see individual drug interactions for specific details