Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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Esbriet
(pirfenidone) + Orsythia
(levonorgestrel/ ethinyl estradiol) |
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Avoid/Use Alternativepirfenidone + ethinyl estradiol (contraceptive) avoid combo if also combined w/ mod-strong CYP2C9, CYP2C19, CYP2D6, or CYP2E1 inhibitor; otherwise, consider alternative or decr. pirfenidone dose to 534 mg tid: combo may incr. pirfenidone levels, risk of adverse effects (hepatic metabolism inhibited) |
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Monitor/Modify Tx |
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lamotrigine
(generic) + Orsythia
(levonorgestrel/ ethinyl estradiol) |
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Monitor/Modify Txlamotrigine + ethinyl estradiol (contraceptive) consider gradual incr. of lamotrigine maint. dose up to 2-fold, initial dose escalation unchanged; no change if also on carbamazepine, phenytoin, phenobarbital, primidone, rifampin, or ritonavir: combo may decr. lamotrigine levels, efficacy; transient incr. of lamotrigine levels, adverse effects may occur during inert tab phase (UGT induced) |
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Additional Considerations |
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lamotrigine
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caution advised with other sodium channel blockers; combo may increase risk of ECG changes, cardiac arrhythmias; additive effects |
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