Interaction Check

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MultiCheck Results - 3 Interactions

Monitor/Modify Tx
Glucophage XR (metformin) + Tri-Lo-Mili (norgestimate/ ethinyl estradiol)
Monitor/Modify Tx metformin + ethinyl estradiol (contraceptive) monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects) metformin + norgestimate (contraceptive) monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)
Caution Advised
Prilosec (omeprazole) + Rytary (carbidopa/ levodopa)
Caution Advised omeprazole + levodopa caution advised w/ oral levodopa: combo may decr. levodopa levels, efficacy (absorption decr. at higher gastric pH)
Additional Considerations
levodopa in Rytary
add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and Crexont; combo may incr. levodopa release rate, levels, risk of adverse effects, decr. duration of efficacy
carbidopa in Rytary
avoid combo with beverages or products containing ethanol and Crexont; combo may incr. carbidopa release rate, levels, risk of adverse effects, decr. duration of efficacy
selumetinib in Koselugo
avoid supplemental vitamin E if daily vitamin E intake greater than recommended or safe limits; combo may incr. risk of bleeding; additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules