epocrates logo
epocrates logo
epocrates logo
  • 0

Interaction Check

epocrates logo

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

  • remove Children's Triaminic Multi-Symptom Fever & Cold
    acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylephrine
  • remove Evekeo
    amphetamine
  • remove norethindrone acetate/ ethinyl estradiol
    generic

multicheck MultiCheck Results - 3 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Children's Triaminic Multi-Symptom Fever & Cold (acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylephrine) + Evekeo (amphetamine)

Avoid/Use Alternative


dextromethorphan + amphetamine

consider alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx


phenylephrine + amphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Children's Triaminic Multi-Symptom Fever & Cold (acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylephrine) + norethindrone acetate/ethinyl estradiol (generic)

Monitor/Modify Tx


acetaminophen + ethinyl estradiol (hormone replacement)

monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown)

Additional Considerations

Smiley face Smiley face phenylephrine in Children's Triaminic Multi-Symptom Fever & Cold

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Children's Triaminic Multi-Symptom Fever & Cold

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face amphetamine in Evekeo

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and Adzenys XR-ODT, Dyanavel XR, Mydayis, generic extended-release orally disintegrating tablet (ER ODT) formulations; combo may incr. amphetamine release rate, levels, risk of adverse effects, decr. duration of efficacy

Help
FDA Reporting Form
 
Download Epocrates from the App Store Download Epocrates from the Play Store
About Us Features Business Solutions Help & Feedback
© 2026 epocrates, Inc.    Terms of Use Privacy Policy Editorial Policy Do Not Sell or Share My Information