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Interaction Check

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Selected Drugs Clear All

  • remove azelastine ophthalmic
    generic
  • remove Cosentyx
    secukinumab
  • remove Gildess Fe 1/ 20
    norethindrone/ ethinyl estradiol
  • remove Voltaren
    diclofenac sodium

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Gildess Fe 1/20 (norethindrone/ ethinyl estradiol) + Voltaren (diclofenac sodium)

Monitor/Modify Tx


ethinyl estradiol (contraceptive) + diclofenac

monitor BP, thrombosis s/sx; use lowest effective diclofenac dose, shortest effective tx duration: combo may incr. risk of HTN, thromboembolism (additive effects)

norethindrone (contraceptive) + diclofenac

monitor thrombosis s/sx, especially w/ concomitant estrogen use; use lowest effective diclofenac dose, shortest effective tx duration: combo may incr. risk of thromboembolism (additive effects)

Additional Considerations

Smiley face Smiley face secukinumab in Cosentyx

caution advised with narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx with immune modulators may reverse this effect, resulting in altered levels of concomitant drugs

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