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Interaction Check

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Selected Drugs Clear All

  • remove Esgic-Plus
    butalbital/ acetaminophen/ caffeine
  • remove Sudafed PE Sinus Pressure + Pain
    acetaminophen/ phenylephrine

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Esgic-Plus (butalbital/ acetaminophen/ caffeine) + Sudafed PE Sinus Pressure + Pain (acetaminophen/ phenylephrine)

Avoid/Use Alternative


acetaminophen + acetaminophen

limit acetaminophen from all sources to standard max acetaminophen doses: combo may incr. acetaminophen levels, risk of hepatotoxicity, other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx


caffeine + phenylephrine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

Additional Considerations

Smiley face Smiley face phenylephrine in Sudafed PE Sinus Pressure + Pain

add MAO inhibitor to Interaction Check if recent (14 days) use

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