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Interaction Check

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Selected Drugs Clear All

  • remove Entresto
    sacubitril/ valsartan
  • remove indomethacin
    generic
  • remove lorazepam
    generic
  • remove oxazepam
    generic
  • remove zafirlukast
    generic

multicheck MultiCheck Results - 4 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Entresto (sacubitril/ valsartan) + indomethacin (generic)

Avoid/Use Alternative


valsartan + indomethacin

consider alternative or monitor renal fxn, potassium, BP: combo may incr. risk of renal impairment, hyperkalemia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

Smiley face Smiley face lorazepam (generic) + oxazepam (generic)

Avoid/Use Alternative


lorazepam + oxazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Entresto (sacubitril/ valsartan) + oxazepam (generic)

Monitor/Modify Tx


sacubitril + oxazepam

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

valsartan + oxazepam

monitor BP: combo may incr. risk of hypotension (additive effects)

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