clozapine + phenobarbital

use alternative or monitor respiratory rate, BP, HR; consider clozapine dose adjustment: combo may decr. clozapine levels, efficacy; may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, clozapine may decr. seizure threshold)

trifluridine + phenobarbital

avoid combo if neonatal seizure use; otherwise, monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

clozapine + trifluridine

monitor CBC, ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, myelosuppression (additive effects)