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Interaction Check

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Selected Drugs Clear All

  • remove Addyi
    flibanserin
  • remove Tylenol w/ Codeine #4
    acetaminophen/ codeine

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Addyi (flibanserin) + Tylenol w/ Codeine #4 (acetaminophen/ codeine)

Avoid/Use Alternative


flibanserin + codeine

avoid combo if antitussive use; otherwise, use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine; additive effects)

Additional Considerations

Smiley face Smiley face codeine in Tylenol w/ Codeine #4

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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