diclofenac + tenofovir alafenamide

monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (additive effects)

diclofenac + emtricitabine

caution advised, especially w/ high-dose diclofenac: combo may incr. levels of both drugs, risk of adverse effects (renal secretion possibly inhibited)

diclofenac + cinacalcet

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

diclofenac + cimetidine

monitor bleeding s/sx; use lowest effective diclofenac dose, shortest duration of concomitant tx: combo may incr. diclofenac levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

cobicistat + cinacalcet

monitor iPTH, calcium, ECG: combo may incr. cinacalcet levels, risk of severe hypocalcemia (including life-threatening), QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited)

tenofovir alafenamide + cimetidine

if tenofovir alafenamide not admin. w/ cobicistat, monitor renal fxn: combo may incr. tenofovir levels, risk of nephrotoxicity, other adverse effects (gut P-gp-mediated transport inhibited)