Interaction Check

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MultiCheck Results - 4 Interactions

Avoid/Use Alternative
Fioricet (butalbital/ acetaminophen/ caffeine) + Sprintec (norgestimate/ ethinyl estradiol)
Avoid/Use Alternative butalbital + ethinyl estradiol (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after butalbital tx: combo may decr. ethinyl estradiol levels, contraceptive efficacy (hepatic metabolism induced, UGT induced) butalbital + norgestimate (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after butalbital tx: combo may decr. norgestimate and active metabolites levels, contraceptive efficacy (hepatic metabolism induced) Monitor/Modify Tx acetaminophen + ethinyl estradiol (contraceptive) monitor thrombosis s/sx: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (mechanism unknown) caffeine + ethinyl estradiol (contraceptive) monitor BP; avoid excessive caffeine intake: combo may incr. caffeine levels, risk of HTN, other adverse effects (hepatic metabolism inhibited, additive effects)