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Interaction Check

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Selected Drugs Clear All

  • remove butalbital/ acetaminophen/ caffeine/ codeine
    generic
  • remove dihydroergotamine nasal
    generic

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face butalbital/acetaminophen/caffeine/codeine (generic) + dihydroergotamine nasal (generic)

Avoid/Use Alternative


codeine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx


caffeine + dihydroergotamine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of severe HTN, vasospasm, ischemia (additive effects)

Additional Considerations

Smiley face Smiley face codeine in butalbital/acetaminophen/caffeine/codeine

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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