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Interaction Check

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Selected Drugs Clear All

  • remove Belbuca
    buprenorphine
  • remove ondansetron
    generic
  • remove Zofran
    ondansetron

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Belbuca (buprenorphine) + ondansetron (generic)

Avoid/Use Alternative


buprenorphine + ondansetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

Smiley face Smiley face Belbuca (buprenorphine) + Zofran (ondansetron)

Avoid/Use Alternative


buprenorphine + ondansetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

Additional Considerations

Smiley face Smiley face buprenorphine in Belbuca

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

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