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Interaction Check

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Selected Drugs Clear All

  • remove Lokelma
    sodium zirconium cyclosilicate
  • remove Quillichew ER
    methylphenidate

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Lokelma (sodium zirconium cyclosilicate) + Quillichew ER (methylphenidate)

Avoid/Use Alternative


sodium zirconium cyclosilicate + methylphenidate

consider alternative w/ some oral methylphenidate ER formulations: combo may alter methylphenidate release, incr. risk of adverse effects or decr. efficacy (altered dissolution of ER methylphenidate at higher gastric pH)

Additional Considerations

Smiley face Smiley face sodium zirconium cyclosilicate in Lokelma

separate administration from other oral drugs by at least 2h; sodium zirconium cyclosilicate may decr. absorption of concomitant oral drugs

Smiley face Smiley face methylphenidate in Quillichew ER

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy

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