Interaction Check

This page cannot be displayed because your browser has been configured to disable JavaScript, also known as "Active Scripting".Please change your settings and refresh the page.

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

MultiCheck Results - 9 Interactions

Avoid/Use Alternative
Hailey 1.5/30 (norethindrone/ ethinyl estradiol) + Lasix (furosemide)
Avoid/Use Alternative ethinyl estradiol (contraceptive) + furosemide use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
Monitor/Modify Tx
Hailey 1.5/30 (norethindrone/ ethinyl estradiol) + Jakafi (ruxolitinib)
Monitor/Modify Tx ethinyl estradiol (contraceptive) + ruxolitinib monitor thrombosis s/sx: combo may incr. risk of thromboembolism (additive effects) norethindrone (contraceptive) + ruxolitinib monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)
Hailey 1.5/30 (norethindrone/ ethinyl estradiol) + Xeljanz XR (tofacitinib)
Monitor/Modify Tx ethinyl estradiol (contraceptive) + tofacitinib monitor thrombosis s/sx: combo may incr. risk of thromboembolism (additive effects) norethindrone (contraceptive) + tofacitinib monitor thrombosis s/sx, especially w/ concomitant estrogen use: combo may incr. risk of thromboembolism (additive effects)
Infumorph (morphine sulfate) + Lasix (furosemide)
Monitor/Modify Tx morphine + furosemide monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope; may decr. furosemide efficacy (additive effects; antagonistic effects, opioids may induce antidiuretic hormone release)
Jakafi (ruxolitinib) + Typhim Vi (typhoid vi polysaccharide vaccine)
Monitor/Modify Tx ruxolitinib + typhoid vaccine if possible, vaccinate at least 2wk before starting ruxolitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)
Jakafi (ruxolitinib) + Xeljanz XR (tofacitinib)
Monitor/Modify Tx ruxolitinib + tofacitinib monitor CBC, thrombosis s/sx: combo may incr. risk of serious infection, myelosuppression, thromboembolism (additive effects)
Typhim Vi (typhoid vi polysaccharide vaccine) + Xeljanz XR (tofacitinib)
Monitor/Modify Tx typhoid vaccine + tofacitinib if possible, vaccinate at least 2wk before starting tofacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)
Additional Considerations
morphine in Infumorph
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy