Interaction Check

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MultiCheck Results - 4 Interactions

Contraindicated
Rectiv (nitroglycerin intra-anal) + Stendra (avanafil)
Contraindicated nitroglycerin + avanafil contraindicated; give nitrates at least 12h after avanafil: combo may incr. risk of severe hypotension, including orthostasis, syncope, myocardial ischemia (additive effects)
Monitor/Modify Tx
duloxetine (generic) + Rectiv (nitroglycerin intra-anal)
Monitor/Modify Tx duloxetine + nitroglycerin monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)
duloxetine (generic) + rivaroxaban (generic)
Monitor/Modify Tx duloxetine + rivaroxaban monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)
duloxetine (generic) + Stendra (avanafil)
Monitor/Modify Tx duloxetine + avanafil monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)
Additional Considerations
duloxetine
add MAO inhibitor to Interaction Check if recent (14 days) use
nitroglycerin in Rectiv
if SL nitroglycerin tab use, caution advised with anticholinergic drugs, tricyclic antidepressants, other drugs that may cause xerostomia; combo may delay vasodilator onset, decr. nitroglycerin peak levels, efficacy; absorption decreased, xerostomia may alter dissolution of SL tab