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Interaction Check

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Selected Drugs Clear All

  • remove Claravis
    isotretinoin
  • remove doxylamine
    generic
  • remove Kenalog-40
    triamcinolone acetonide
  • remove nabumetone
    generic
  • remove Pulmicort Respules
    budesonide inhaled
  • remove Rexulti
    brexpiprazole
  • remove Zepbound
    tirzepatide
  • remove Zyprexa
    olanzapine

multicheck MultiCheck Results - 9 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face doxylamine (generic) + Rexulti (brexpiprazole)

Avoid/Use Alternative


doxylamine + brexpiprazole

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

Smiley face Smiley face doxylamine (generic) + Zyprexa (olanzapine)

Avoid/Use Alternative


doxylamine + olanzapine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

Smiley face Smiley face Rexulti (brexpiprazole) + Zyprexa (olanzapine)

Avoid/Use Alternative


brexpiprazole + olanzapine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, extrapyramidal symptoms, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

Smiley face Smiley face Kenalog-40 (triamcinolone acetonide) + nabumetone (generic)

Monitor/Modify Tx


triamcinolone + nabumetone

monitor BP, bleeding s/sx: combo may incr. risk of HTN, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Smiley face Smiley face Kenalog-40 (triamcinolone acetonide) + Zepbound (tirzepatide)

Monitor/Modify Tx


triamcinolone + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Rexulti (brexpiprazole) + Zepbound (tirzepatide)

Monitor/Modify Tx


brexpiprazole + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Smiley face Smiley face Zepbound (tirzepatide) + Zyprexa (olanzapine)

Monitor/Modify Tx


tirzepatide + olanzapine

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Caution Advised

Smiley face Smiley face Claravis (isotretinoin) + Kenalog-40 (triamcinolone acetonide)

Caution Advised


isotretinoin + triamcinolone

caution advised: combo may incr. risk of bone loss (additive effects)

Smiley face Smiley face Kenalog-40 (triamcinolone acetonide) + Pulmicort Respules (budesonide inhaled)

Caution Advised


triamcinolone + budesonide inhaled

caution advised: combo may incr. risk of systemic corticosteroid effects including Cushing syndrome and adrenal suppression, serious infection, other adverse effects (additive effects, duplicate therapy)

Additional Considerations

Smiley face Smiley face tirzepatide in Zepbound

caution advised with oral drugs, especially narrow therapeutic index; tirzepatide delays gastric emptying, may alter absorption of concomitant oral drugs

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