Selected Drugs Clear All
MultiCheck Results
- 10
Interactions
Contraindicated |
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Cartia XT
(diltiazem) + Mitigare
(colchicine) |
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Contraindicateddiltiazem + colchicine CV RISK REDUCTION: avoid combo if renal or hepatic impairment; otherwise, monitor CK, myopathy s/sx; GOUT or FMF: contraindicated if renal or hepatic impairment; otherwise, use alternative or decr. colchicine dose during and x14 days after diltiazem use as follows: GOUT PROPHYLAXIS: give colchicine 0.3-0.6 mg/day divided qd-bid; ACUTE GOUT: avoid combo if receiving colchicine for prophylaxis; otherwise, give colchicine 1.2 mg x1 only; FMF: decr. max colchicine dose to 1.2 mg/day divided qd-bid: combo may incr. colchicine levels, risk of myopathy, rhabdomyolysis, other life-threatening toxicity (hepatic metabolism inhibited, P-gp-mediated transport inhibited) |
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Avoid/Use Alternative |
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Mitigare
(colchicine) + norelgestromin/ethinyl estradiol transdermal
(generic) |
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Avoid/Use Alternativecolchicine + ethinyl estradiol (contraceptive) CV RISK REDUCTION: consider monitoring CK, myopathy s/sx; GOUT or FMF: use alternative or consider decr. colchicine dose during and x14 days after ethinyl estradiol use: combo may incr. colchicine levels, risk of myopathy, rhabdomyolysis, other life-threatening toxicity (hepatic metabolism inhibited) |
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Mitigare
(colchicine) + Tri-Estarylla
(norgestimate/ ethinyl estradiol) |
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Avoid/Use Alternativecolchicine + ethinyl estradiol (contraceptive) CV RISK REDUCTION: consider monitoring CK, myopathy s/sx; GOUT or FMF: use alternative or consider decr. colchicine dose during and x14 days after ethinyl estradiol use: combo may incr. colchicine levels, risk of myopathy, rhabdomyolysis, other life-threatening toxicity (hepatic metabolism inhibited) |
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norelgestromin/ethinyl estradiol transdermal
(generic) + Tri-Estarylla
(norgestimate/ ethinyl estradiol) |
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Avoid/Use Alternativeethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive) avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy) norelgestromin (contraceptive) + norgestimate (contraceptive) avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy) |
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Monitor/Modify Tx |
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Cartia XT
(diltiazem) + Kenalog-40
(triamcinolone acetonide) |
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Cartia XT
(diltiazem) + norelgestromin/ethinyl estradiol transdermal
(generic) |
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Monitor/Modify Txdiltiazem + ethinyl estradiol (contraceptive) monitor BP, thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects) |
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Cartia XT
(diltiazem) + Tri-Estarylla
(norgestimate/ ethinyl estradiol) |
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Monitor/Modify Txdiltiazem + ethinyl estradiol (contraceptive) monitor BP, thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day: combo may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects) |
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Kenalog-40
(triamcinolone acetonide) + norelgestromin/ethinyl estradiol transdermal
(generic) |
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Kenalog-40
(triamcinolone acetonide) + Tri-Estarylla
(norgestimate/ ethinyl estradiol) |
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Additional Considerations |
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diltiazem
in Cartia XT
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avoid combo with beverages or products containing ethanol and Cardizem CD, Cartia XT, some generic extended-release (ER) capsules; combo may incr. diltiazem release rate, levels, risk of adverse effects, decr. duration of efficacy |
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