Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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Children's Dimetapp Multi-Symptom Cold & Flu
(acetaminophen/ diphenhydramine) + hydrocodone/homatropine
(generic) |
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Avoid/Use Alternativediphenhydramine + hydrocodone avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects) Caution Adviseddiphenhydramine + homatropine caution advised: combo may incr. anticholinergic adverse effects (additive effects) |
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Additional Considerations |
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hydrocodone
in hydrocodone/homatropine
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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