Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
||
|
Elavil
(amitriptyline) + Hycodan
(hydrocodone/ homatropine) |
||
Avoid/Use Alternativeamitriptyline + hydrocodone avoid combo if antitussive use; otherwise use alternative or monitor respiratory rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, other anticholinergic adverse effects (additive effects) Caution Advisedamitriptyline + homatropine caution advised, especially w/ high environmental temperature: combo may incr. anticholinergic adverse effects, risk of hyperpyrexia (additive effects) |
||
Additional Considerations |
||
|
amitriptyline
in Elavil
|
||
|
add MAO inhibitor to Interaction Check if recent (14 days) use |
||
|
hydrocodone
in Hycodan
|
||
|
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
||