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Interaction Check

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Selected Drugs Clear All

  • remove Chinese goldenseal
    goldenseal (Hydrastis canadensis)
  • remove Virtussin DAC
    codeine/ pseudoephedrine/ guaifenesin

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Chinese goldenseal (goldenseal (Hydrastis canadensis)) + Virtussin DAC (codeine/ pseudoephedrine/ guaifenesin)

Avoid/Use Alternative


goldenseal + codeine

use alternative or monitor respiratory rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, may incr. production of active metabolite morphine)

Additional Considerations

Smiley face Smiley face goldenseal in Chinese goldenseal

goldenseal may contain varying amounts of berberine and other constituents; interaction potential dependent upon daily berberine intake, may incr. risk of bleeding, hypoglycemia, hypotensive effects

Smiley face Smiley face codeine in Virtussin DAC

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face pseudoephedrine in Virtussin DAC

add MAO inhibitor to Interaction Check if recent (14 days) use

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