Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Monitor/Modify Tx |
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losartan/hydrochlorothiazide
(generic) + Roxanol
(morphine sulfate) |
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Monitor/Modify Txhydrochlorothiazide + morphine monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope; may decr. hydrochlorothiazide efficacy (additive effects; antagonistic effects, opioids may induce antidiuretic hormone release) losartan + morphine monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects) |
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Additional Considerations |
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morphine
in Roxanol
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some morphine extended-release (ER) capsules; combo may incr. morphine release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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