Interaction Check

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MultiCheck Results - 4 Interactions

Avoid/Use Alternative
Cardene SR (nicardipine) + Oxaydo (oxycodone)
Avoid/Use Alternative nicardipine + oxycodone use alternative or monitor respiratory rate, BP; consider decr. oxycodone dose: combo may incr. oxycodone levels, risk of CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, additive effects)
Monitor/Modify Tx
Cardene SR (nicardipine) + Hecoria (tacrolimus)
Monitor/Modify Tx nicardipine + tacrolimus monitor tacrolimus levels, ECG, BP, renal fxn: combo may incr. tacrolimus levels, risk of QT prolongation, cardiac arrhythmias, nephrotoxicity, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)
Hecoria (tacrolimus) + Kerlone (betaxolol)
Monitor/Modify Tx tacrolimus + betaxolol monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
Kerlone (betaxolol) + Oxaydo (oxycodone)
Monitor/Modify Tx betaxolol + oxycodone monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)
Additional Considerations
tacrolimus in Hecoria
monitor tacrolimus levels in combo with HCV Direct Acting Antiviral (DAA) tx; viral eradication may improve hepatic metabolic function, alter tacrolimus levels, efficacy avoid combo with beverages or products containing ethanol and tacrolimus extended-release (ER) formulations; combo may incr. tacrolimus release rate, levels, risk of adverse effects, decr. duration of efficacy
oxycodone in Oxaydo
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use add MAO inhibitor to Interaction Check if recent (14 days) use