Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
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Panlor SS
(acetaminophen/ caffeine/ dihydrocodeine) + Sudafed PE Sinus Congestion Night
(diphenhydramine/ phenylephrine) |
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Avoid/Use Alternativedihydrocodeine + diphenhydramine use alternative or monitor respiratory rate, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. dihydrocodeine levels, risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention, other adverse effects; may decr. active metabolite dihydromorphine levels, efficacy (hepatic metabolism inhibited, decr. conversion to dihydromorphine, additive effects) Monitor/Modify Txcaffeine + phenylephrine monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects) |
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Additional Considerations |
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dihydrocodeine
in Panlor SS
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use |
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phenylephrine
in Sudafed PE Sinus Congestion Night
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add MAO inhibitor to Interaction Check if recent (14 days) use |
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