Interaction Check

This page cannot be displayed because your browser has been configured to disable JavaScript, also known as "Active Scripting".Please change your settings and refresh the page.

Sign in to access our clinical decision support tools

Sign in Create Account

Selected Drugs Clear All

MultiCheck Results - 6 Interactions

Avoid/Use Alternative
Lorbrena (lorlatinib) + Low-Ogestrel (norgestrel/ ethinyl estradiol)
Avoid/Use Alternative lorlatinib + ethinyl estradiol (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after lorlatinib tx; monitor BP: combo may decr. ethinyl estradiol levels, contraceptive efficacy; may incr. risk of HTN (hepatic metabolism induced, P-gp-mediated transport induced, UGT induced; additive effects) lorlatinib + norgestrel (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after lorlatinib tx: combo may decr. norgestrel levels, contraceptive efficacy (hepatic metabolism induced)
Lorbrena (lorlatinib) + Syeda (drospirenone/ ethinyl estradiol)
Avoid/Use Alternative lorlatinib + drospirenone (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after lorlatinib tx: combo may decr. drospirenone levels, contraceptive efficacy (hepatic metabolism induced) lorlatinib + ethinyl estradiol (contraceptive) use additional non-hormonal or alternative contraception during and x28 days after lorlatinib tx; monitor BP: combo may decr. ethinyl estradiol levels, contraceptive efficacy; may incr. risk of HTN (hepatic metabolism induced, P-gp-mediated transport induced, UGT induced; additive effects)
Low-Ogestrel (norgestrel/ ethinyl estradiol) + Syeda (drospirenone/ ethinyl estradiol)
Avoid/Use Alternative ethinyl estradiol (contraceptive) + ethinyl estradiol (contraceptive) avoid combo: combo may incr. risk of HTN, thromboembolism, endometrial hyperplasia, other adverse effects (additive effects, duplicate therapy) norgestrel (contraceptive) + drospirenone (contraceptive) avoid combo: combo may incr. risk of thromboembolism, other adverse effects (additive effects, duplicate therapy)