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Interaction Check

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Selected Drugs Clear All

  • remove Dilantin
    phenytoin
  • remove magnesium citrate
    generic
  • remove Mirvaso
    brimonidine topical
  • remove Primatene Mist
    epinephrine inhaled
  • remove trospium
    generic

multicheck MultiCheck Results - 5 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Primatene Mist (epinephrine inhaled) + trospium (generic)

Avoid/Use Alternative


epinephrine inhaled + trospium

avoid combo: combo may incr. risk of tachycardia (additive effects)

Monitor/Modify Tx

Smiley face Smiley face Dilantin (phenytoin) + magnesium citrate (generic)

Monitor/Modify Tx


phenytoin + magnesium citrate

consider giving oral phenytoin at least 2h before or 6h after magnesium citrate; monitor phenytoin levels: combo may decr. phenytoin levels, efficacy; may alter seizure control (absorption decreased via chelation; antagonistic effects, magnesium citrate may decr. seizure threshold)

Caution Advised

Smiley face Smiley face Dilantin (phenytoin) + Mirvaso (brimonidine topical)

Caution Advised


phenytoin + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Smiley face Smiley face Dilantin (phenytoin) + trospium (generic)

Caution Advised


phenytoin + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Smiley face Smiley face Mirvaso (brimonidine topical) + trospium (generic)

Caution Advised


brimonidine topical + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Additional Considerations

Smiley face Smiley face trospium

avoid combo with beverages or products containing ethanol within 2h of trospium extended-release (ER) capsules administration; combo may incr. trospium release rate, levels, risk of adverse effects, decr. duration of efficacy

Smiley face Smiley face magnesium citrate

separate administration from other oral drugs by at least 1h; magnesium citrate may decr. absorption of concomitant oral drugs

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