Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Monitor/Modify Tx |
||
|
Atripla
(efavirenz/ emtricitabine/ tenofovir disoproxil) + Dovato
(dolutegravir/ lamivudine) |
||
Monitor/Modify Txefavirenz + dolutegravir give additional dolutegravir dose 12h after fixed-dose combo when dolutegravir is given as part of a fixed-dose combo; otherwise, incr. dolutegravir dose frequency to bid in tx-naive or tx-experienced INSTI-naive pts; consider alternatives in INSTI-experienced pts w/ INSTI resistance: combo may decr. dolutegravir levels, efficacy (hepatic metabolism induced, UGT induced, P-gp-mediated transport induced) |
||
|
Dovato
(dolutegravir/ lamivudine) + Gelusil
(aluminum hydroxide/ magnesium hydroxide/ simethicone) |
||
Monitor/Modify Txdolutegravir + aluminum hydroxide give aluminum hydroxide 6h before or 4h after dolutegravir when given in combo w/ rilpivirine as a complete regimen; otherwise, give aluminum hydroxide 6h before or 2h after dolutegravir: combo may decr. dolutegravir levels, efficacy (absorption decreased via chelation) dolutegravir + magnesium hydroxide give magnesium hydroxide 6h before or 4h after dolutegravir when given in combo w/ rilpivirine as a complete regimen; otherwise, give magnesium hydroxide 6h before or 2h after dolutegravir: combo may decr. dolutegravir levels, efficacy (absorption decreased via chelation) |
||
Additional Considerations |
||
|
lamivudine
in Dovato
|
||
|
avoid combo of lamivudine oral solution with oral products containing sorbitol; may give lamivudine tab formulation or monitor virologic response more frequently if combo cannot be avoided; sorbitol may decr. bioavailability of lamivudine, resulting in decr. levels, efficacy |
||