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Interaction Check

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Selected Drugs Clear All

  • remove Idacio (adalimumab-aacf)
    adalimumab
  • remove Orajel PM 4X Medicated Toothache & Gum Pain Relief Cream
    benzalkonium chloride/ benzocaine/ menthol/ zinc chloride oropharyngeal
  • remove Ultracet
    tramadol/ acetaminophen

multicheck MultiCheck Results - 1 Interaction

Smiley face Smiley face

Caution Advised

Smiley face Smiley face Orajel PM 4X Medicated Toothache & Gum Pain Relief Cream (benzalkonium chloride/ benzocaine/ menthol/ zinc chloride oropharyngeal) + Ultracet (tramadol/ acetaminophen)

Caution Advised


benzocaine topical + acetaminophen

caution advised: combo may incr. risk of methemoglobinemia (additive effects)

Additional Considerations

Smiley face Smiley face adalimumab in Idacio (adalimumab-aacf)

caution advised with narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx with immune modulators may reverse this effect, resulting in altered levels of concomitant drugs

Smiley face Smiley face tramadol in Ultracet

consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use

add MAO inhibitor to Interaction Check if recent (14 days) use

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