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Interaction Check

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Selected Drugs Clear All

  • remove Pamprin Multi-Symptom Maximum Strength
    acetaminophen/ pamabrom/ pyrilamine
  • remove Tylenol Cold + Flu Severe Night
    acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylephrine

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Pamprin Multi-Symptom Maximum Strength (acetaminophen/ pamabrom/ pyrilamine) + Tylenol Cold + Flu Severe Night (acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylephrine)

Avoid/Use Alternative


acetaminophen + acetaminophen

limit acetaminophen from all sources to standard max acetaminophen doses: combo may incr. acetaminophen levels, risk of hepatotoxicity, other adverse effects (additive effects, duplicate therapy)

pyrilamine + chlorpheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Additional Considerations

Smiley face Smiley face phenylephrine in Tylenol Cold + Flu Severe Night

add MAO inhibitor to Interaction Check if recent (14 days) use

Smiley face Smiley face dextromethorphan in Tylenol Cold + Flu Severe Night

add MAO inhibitor to Interaction Check if recent (14 days) use

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