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Selected Drugs Clear All

MultiCheck Results - 4 Interactions

Avoid/Use Alternative
phenylephrine (generic) + pseudoephedrine (generic)
Avoid/Use Alternative phenylephrine + pseudoephedrine avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)
Monitor/Modify Tx
phenylephrine (generic) + Toprol-XL (metoprolol succinate)
Monitor/Modify Tx phenylephrine + metoprolol monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
pseudoephedrine (generic) + Toprol-XL (metoprolol succinate)
Monitor/Modify Tx pseudoephedrine + metoprolol monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)
Rinvoq (upadacitinib) + Toprol-XL (metoprolol succinate)
Monitor/Modify Tx upadacitinib + metoprolol monitor BP, HR if taking upadacitinib dose 45 mg qd; consider lower metoprolol dose: combo may incr. metoprolol levels, risk of hypotension, bradycardia, AV block, other adverse effects (hepatic metabolism inhibited)
Additional Considerations
metoprolol in Toprol-XL
avoid combo with beverages or products containing ethanol and metoprolol extended-release (ER) sprinkle; combo may incr. metoprolol release rate, levels, risk of adverse effects, decr. duration of efficacy
phenylephrine
add MAO inhibitor to Interaction Check if recent (14 days) use
pseudoephedrine
add MAO inhibitor to Interaction Check if recent (14 days) use