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Interaction Check

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Selected Drugs Clear All

  • remove ethambutol
    generic
  • remove Mircette
    desogestrel/ ethinyl estradiol
  • remove Rybelsus
    semaglutide

multicheck MultiCheck Results - 2 Interactions

Smiley face Smiley face

Monitor/Modify Tx

Smiley face Smiley face Mircette (desogestrel/ ethinyl estradiol) + Rybelsus (semaglutide)

Monitor/Modify Tx


desogestrel (contraceptive) + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

ethinyl estradiol (contraceptive) + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

Additional Considerations

Smiley face Smiley face semaglutide in Rybelsus

caution advised with oral drugs, especially narrow therapeutic index; oral/SC semaglutide delays gastric emptying, may alter absorption of concomitant oral drugs

administer oral semaglutide at least 30 min before other oral drugs; combo may decr. oral semaglutide absorption, efficacy

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