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Interaction Check

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Selected Drugs Clear All

  • remove Cobenfy
    xanomeline/ trospium
  • remove Genosyl
    nitric oxide inhaled
  • remove Liqrev
    sildenafil
  • remove Opsumit
    macitentan
  • remove Tadliq
    tadalafil
  • remove Tracleer
    bosentan
  • remove Tyvaso DPI
    treprostinil inhaled

multicheck MultiCheck Results - 9 Interactions

Smiley face Smiley face

Avoid/Use Alternative

Smiley face Smiley face Liqrev (sildenafil) + Tadliq (tadalafil)

Avoid/Use Alternative


sildenafil + tadalafil

avoid combo: combo may incr. risk of hypotension, auditory, vestibular, other adverse effects (additive effects, duplicate therapy)

Smiley face Smiley face Tadliq (tadalafil) + Tracleer (bosentan)

Avoid/Use Alternative


tadalafil + bosentan

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metabolism induced)

Monitor/Modify Tx

Smiley face Smiley face Cobenfy (xanomeline/ trospium) + Tadliq (tadalafil)

Monitor/Modify Tx


xanomeline + tadalafil

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (GI metabolism possibly inhibited)

Smiley face Smiley face Genosyl (nitric oxide inhaled) + Liqrev (sildenafil)

Monitor/Modify Tx


nitric oxide + sildenafil

monitor BP: combo may incr. risk of hypotension (additive effects)

Smiley face Smiley face Genosyl (nitric oxide inhaled) + Tadliq (tadalafil)

Monitor/Modify Tx


nitric oxide + tadalafil

monitor BP: combo may incr. risk of hypotension (additive effects)

Smiley face Smiley face Genosyl (nitric oxide inhaled) + Tyvaso DPI (treprostinil inhaled)

Monitor/Modify Tx


nitric oxide + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including syncope (additive effects)

Smiley face Smiley face Liqrev (sildenafil) + Tracleer (bosentan)

Monitor/Modify Tx


sildenafil + bosentan

PULMONARY HTN: consider sildenafil dose adjustment; ERECTILE DYSFUNCTION: caution advised: combo may decr. sildenafil levels, efficacy (hepatic metabolism induced)

Smiley face Smiley face Liqrev (sildenafil) + Tyvaso DPI (treprostinil inhaled)

Monitor/Modify Tx


sildenafil + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including syncope (additive effects)

Smiley face Smiley face Tadliq (tadalafil) + Tyvaso DPI (treprostinil inhaled)

Monitor/Modify Tx


tadalafil + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including syncope (additive effects)

Additional Considerations

Smiley face Smiley face trospium in Cobenfy

avoid combo with beverages or products containing ethanol within 2h of trospium extended-release (ER) capsules administration; combo may incr. trospium release rate, levels, risk of adverse effects, decr. duration of efficacy

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