Selected Drugs Clear All
MultiCheck Results
- 5
Interactions
Avoid/Use Alternative |
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Lortab
(hydrocodone/ acetaminophen) + Motofen
(difenoxin/ atropine) |
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Avoid/Use Alternativehydrocodone + difenoxin avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects) Caution Advisedhydrocodone + atropine caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects) |
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Caution Advised |
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loperamide
(generic) + Lortab
(hydrocodone/ acetaminophen) |
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Caution Advisedloperamide + hydrocodone caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects) |
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loperamide
(generic) + Motofen
(difenoxin/ atropine) |
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Caution Advisedloperamide + atropine caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects) loperamide + difenoxin caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects) |
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Additional Considerations |
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hydrocodone
in Lortab
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consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
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