Selected Drugs Clear All
MultiCheck Results
- 10
Interactions
Avoid/Use Alternative |
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clobazam
(generic) + Valtoco
(diazepam nasal) |
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Avoid/Use Alternativeclobazam + diazepam use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy) |
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Monitor/Modify Tx |
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Cerebyx
(fosphenytoin) + clobazam
(generic) |
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Monitor/Modify Txfosphenytoin + clobazam monitor respiratory rate: combo may incr. clobazam active metabolite levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism induced, incr. active metabolite formation, additive effects) |
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Cerebyx
(fosphenytoin) + Qudexy XR
(topiramate) |
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Monitor/Modify Txfosphenytoin + topiramate monitor phenytoin levels: combo may incr. phenytoin levels, risk of toxicity; may decr. topiramate levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metabolism inhibited; hepatic metabolism induced; additive effects) |
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Cerebyx
(fosphenytoin) + rufinamide
(generic) |
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Monitor/Modify Txfosphenytoin + rufinamide monitor phenytoin levels: combo may incr. phenytoin levels, risk of toxicity; may decr. rufinamide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (mechanism unknown; hepatic metabolism induced; additive effects) |
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Cerebyx
(fosphenytoin) + Valtoco
(diazepam nasal) |
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Monitor/Modify Txfosphenytoin + diazepam monitor respiratory rate, phenytoin levels; use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. phenytoin levels, incr. risk of adverse effects or decr. efficacy; may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (mechanism unknown, hepatic metabolism possibly altered; hepatic metabolism induced; additive effects) |
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clobazam
(generic) + Qudexy XR
(topiramate) |
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Monitor/Modify Txclobazam + topiramate monitor respiratory rate: combo may incr. clobazam and active metabolite levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects) |
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clobazam
(generic) + rufinamide
(generic) |
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Monitor/Modify Txclobazam + rufinamide monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects) |
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Qudexy XR
(topiramate) + Valtoco
(diazepam nasal) |
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Monitor/Modify Txtopiramate + diazepam monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects) |
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rufinamide
(generic) + Valtoco
(diazepam nasal) |
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Monitor/Modify Txrufinamide + diazepam monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects) |
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Caution Advised |
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Qudexy XR
(topiramate) + rufinamide
(generic) |
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Caution Advisedtopiramate + rufinamide caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects) |
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Additional Considerations |
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topiramate
in Qudexy XR
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beverages or products containing ethanol are contraindicated within 6h of topiramate extended-release (ER) capsules administration; combo may incr. topiramate release rate, levels, risk of adverse effects, decr. duration of efficacy |
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