Selected Drugs Clear All
MultiCheck Results
- 3
Interactions
Avoid/Use Alternative |
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Bonjesta
(doxylamine/ pyridoxine) + Wakix
(pitolisant) |
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Avoid/Use Alternativedoxylamine + pitolisant avoid combo: combo may decr. efficacy of both drugs (antagonistic effects) |
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Monitor/Modify Tx |
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Aplenzin
(bupropion hydrobromide) + Wakix
(pitolisant) |
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Monitor/Modify Txbupropion + pitolisant monitor ECG; if adding bupropion to stable pitolisant tx, decr. pitolisant dose by 50%; if adding pitolisant to existing bupropion tx in PEDS PTS <40kg: adjust pitolisant max dose to 8.9 mg qd; ADULTS and PEDS PTS 40kg or more: adjust pitolisant max dose to 17.8 mg qd: combo may incr. pitolisant levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited) |
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Caution Advised |
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Kyleena
(levonorgestrel intrauterine device) + Wakix
(pitolisant) |
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Caution Advisedlevonorgestrel intrauterine device (contraceptive) + pitolisant caution advised: combo may decr. levonorgestrel levels, contraceptive efficacy (hepatic metabolism possibly induced) |
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Additional Considerations |
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bupropion
in Aplenzin
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caution advised with concomitant drugs if smoking cessation use; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs add MAO inhibitor to Interaction Check if recent (14 days) use |
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