Interaction Check

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MultiCheck Results - 3 Interactions

Avoid/Use Alternative
clozapine (generic) + phenobarbital (generic)
Avoid/Use Alternative clozapine + phenobarbital use alternative or monitor respiratory rate, BP, HR; consider clozapine dose adjustment: combo may decr. clozapine levels, efficacy; may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, clozapine may decr. seizure threshold)
Lonsurf (trifluridine/ tipiracil) + phenobarbital (generic)
Avoid/Use Alternative trifluridine + phenobarbital avoid combo if neonatal seizure use; otherwise, monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)
Monitor/Modify Tx
clozapine (generic) + Lonsurf (trifluridine/ tipiracil)
Monitor/Modify Tx clozapine + trifluridine monitor CBC, ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, myelosuppression (additive effects)
Additional Considerations
rilonacept in Arcalyst
caution advised with narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx with immune modulators may reverse this effect, resulting in altered levels of concomitant drugs